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Disease Profile
Malakoplakia
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
Unknown
Age of onset
Adult
ICD-10
-
Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
Malacoplakia
Categories
Digestive Diseases
Summary
Malakoplakia is a rare chronic inflammatory disease. It most commonly involves the
The cause of malakoplakia is not well understood. It is thought to be related to an issue with the function of one's macrophages, which are one type of
Symptoms
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
Medical Terms | Other Names |
Learn More:
HPO ID
|
---|---|---|
80%-99% of people have these symptoms | ||
Abdominal pain |
Pain in stomach
Stomach pain
[ more ] |
0002027 |
Abnormal bleeding |
Bleeding tendency
|
0001892 |
Abnormality of the menstrual cycle | 0000140 | |
Diarrhea |
Watery stool
|
0002014 |
Dysuria |
Painful or difficult urination
|
0100518 |
Fever | 0001945 | |
Hematuria |
Blood in urine
|
0000790 |
Papule | 0200034 | |
High urine protein levels
Protein in urine
[ more ] |
0000093 | |
Pruritus |
Itching
Itchy skin
Skin itching
[ more ] |
0000989 |
Skin rash | 0000988 | |
Skin ulcer |
Open skin sore
|
0200042 |
Subcutaneous nodule |
Firm lump under the skin
Growth of abnormal tissue under the skin
[ more ] |
0001482 |
Urinary bladder inflammation | 0100577 | |
Urinary hesitancy |
Difficulty with flow
|
0000019 |
Urinary urgency |
Overactive bladder
|
0000012 |
30%-79% of people have these symptoms | ||
Follicular hyperplasia | 0002729 | |
Decreased immune function
|
0002721 | |
5%-29% of people have these symptoms | ||
Abnormality of the neck | 0000464 | |
Abnormality of the tongue |
Abnormal tongue
Tongue abnormality
[ more ] |
0000157 |
Chest pain | 0100749 | |
Cough |
Coughing
|
0012735 |
Colon tumor
|
0100273 | |
Neoplasm of the rectum |
Rectal tumor
|
0100743 |
Orchitis |
Inflammation of testicles
|
0100796 |
Prostate neoplasm | 0100787 |
Cause
Related diseases
Related diseases are conditions that have similar signs and symptoms. A health care provider may consider these conditions in the table below when making a diagnosis. Please note that the table may not include all the possible conditions related to this disease.
Conditions with similar signs and symptoms from Orphanet
|
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Depending on the organ involved, differential diagnoses include primary or metastatic malignancies, inflammatory diseases (sarcoidosis, Crohn's disease; see these terms), infections (tuberculosis, Whipple disease; see these terms), and cutaneous fungal infections.
Visit the Orphanet disease page for more information.
|
Organizations
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Organizations Providing General Support
-
American Association of Kidney Patients
3505 E. Frontage Rd., Suite 315
Tampa, FL 33607-1796
Toll-free: 800-749-2257
Telephone: 813-636-8100
Fax: 813-636-8122
E-mail: [email protected]
Website: https://www.aakp.org -
American Kidney Fund (AKF)
11921 Rockville Pike
Suite 300
Rockville, MD 20852
Toll-free: 866-300-2900
E-mail: [email protected]
Website: https://www.kidneyfund.org -
National Kidney Foundation
30 East 33rd Street
New York, NY 10016
Toll-free: 800-622-9010
Telephone: 212-889-2210
Fax: 212-689-9261
E-mail: [email protected]
Website: https://www.kidney.org/ -
The Kidney Foundation of Canada
700-15 Gervais Drive
Toronto Ontario M3C 1Y8
Canada
Toll-free: 800-387-4474
Telephone: 416-445-0373
Fax: 416-445-7440
E-mail: [email protected]
Website: https://www.kidney.on.ca
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Where to Start
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), provides information on chronic kidney disease that you may find helpful. Click on the link above to view this information.
In-Depth Information
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Malakoplakia. Click on the link to view a sample search on this topic.
References
- Amira M Elbendary. Malakoplakia. Medscape. Jan 19, 2016; https://emedicine.medscape.com/article/1055606-overview.
- João Paulo Junqueira Magalhães Afonso, Patricia Naomi Ando, Maria Helena Valle de Queiroz Padilha, Nilceo Schwery Michalany, Adriana Maria Porro. Cutaneous malakoplakia: case report and review. An Bras Dermatol. 2013 May-Jun; 88(3):432-437. https://www.ncbi.nlm.nih.gov/pubmed/23793204.
- Tolkoff-Rubin NE, Rubin RH, Contran RS. Urinary Tract Infection, Pyelonephritis, and Reflux Nephropathy. In: Brenner BM, Levine SA. Brenner & Rector's THE KIDNEY 8th ed. Philadelphia, PA: 2008;
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