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5 Facts you should know about
Hemophilia A
1
It is an X-linked recessive disorder, primarily affecting males, while females can be carriers
2
Hemophilia A, the most common hereditary disorder of hemostasis, occurs in 1 out of 5000 males and accounts for 80% of hemophilia cases
3
About 5-10% of people with hemophilia A are affected because they make a dysfunctional version of the factor VIII protein, while the remainder are affected because they produce factor VIII in insufficient amounts
4
Bleeding in hemophilia results from defective fibrin stabilization secondary to inadequate fibrin generation, which results in a failure of secondary hemostasis
5
Hemarthrosis, or bleeding into joints, is one of the most common and debilitating complications of severe hemophilia A
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