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5 Facts you should know about
Evans syndrome
1
Evans syndrome is a rare autoimmune disorder characterized by the simultaneous or sequential development of autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP)
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It primarily affects children and young adults, presenting with symptoms of anemia (fatigue, pallor) due to red blood cell destruction and bleeding tendencies due to low platelet counts
3
The exact cause of Evans syndrome is unclear, but it involves an abnormal immune response leading to the destruction of red blood cells and platelets by autoantibodies
4
Diagnosis involves blood tests demonstrating a positive direct antiglobulin test (Coombs test) for AIHA and low platelet count for ITP, often requiring exclusion of other causes of cytopenias
5
Management aims to control symptoms and prevent complications, utilizing corticosteroids, immunosuppressive therapies, intravenous immunoglobulins (IVIG), splenectomy, or, in severe cases, hematopoietic stem cell transplantation
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