5 Facts you should know about

Aplastic anemia

Aplastic anemia (AA) should be suspected in patients presenting with pancytopenia and hypocellular bone marrow

Symptoms may include fatigue, weakness, dizziness, shortness of breath, frequent infections, and bleeding

There is a well-recognized bimodal age distribution with one peak in mid to late childhood and another in the elderly

In ~10% of patients, a history of non-viral hepatitis can precede the onset of AA

For newly diagnosed severe aplastic anemia, bone marrow transplant should be pursued in all pediatric patients and in younger adult patients when a matched sibling donor is available

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