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Disease Profile
Abdominal aortic aneurysm
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
#N/A
Age of onset
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ICD-10
#N/A
Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
Aneurysm, abdominal aortic
Categories
Blood Diseases; Congenital and Genetic Diseases; Heart Diseases
Summary
Abdominal aortic aneurysms (AAAs) are aneurysms that occur in the part of the aorta that passes through the abdomen. They may occur at any age, but are most common in men between 50 and 80 years of age. Many people with an AAA have no symptoms, but some people have a pulsing sensation in the abdomen and/or pain in the back.[1] If the aneurysm ruptures, it may cause deep, severe pain; nausea; vomiting; fast heart rate; clammy skin; and/or shock.[1][2] About 20% of AAAs eventually rupture and are often fatal.[1] The condition has multiple genetic and environmental
Symptoms
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
Medical Terms | Other Names |
Learn More:
HPO ID
|
---|---|---|
80%-99% of people have these symptoms | ||
Dysphasia | 0002357 | |
Frontotemporal cerebral atrophy | 0006892 | |
Frontotemporal |
0002145 | |
Grammar-specific speech disorder | 0006977 | |
Memory impairment |
Forgetfulness
Memory loss
Memory problems
Poor memory
[ more ] |
0002354 |
Spoken Word Recognition Deficit | 0030391 | |
Temporal cortical atrophy | 0007112 | |
Thickened nuchal skin fold |
Thickened skin folds of neck
Thickened skin over the neck
[ more ] |
0000474 |
30%-79% of people have these symptoms | ||
Abnormal brain FDG positron emission tomography | 0012658 | |
Abnormality of the cerebral white matter | 0002500 | |
Alexia |
Text blindness
Word blindness
[ more ] |
0010523 |
Anxiety |
Excessive, persistent worry and fear
|
0000739 |
Apraxia | 0002186 | |
Depressivity |
Depression
|
0000716 |
0011204 | ||
5%-29% of people have these symptoms | ||
Abnormal lower motor neuron morphology | 0002366 | |
Astrocytosis | 0002446 | |
Dysgraphia | 0010526 | |
Motor aphasia |
Loss of expressive speech
|
0002427 |
Mutism |
Inability to speak
Muteness
[ more ] |
0002300 |
Parkinsonism | 0001300 | |
Perseveration | 0030223 | |
Personality changes |
Personality change
|
0000751 |
Restlessness | 0000711 | |
Senile plaques | 0100256 | |
Percent of people who have these symptoms is not available through HPO | ||
Abdominal aortic aneurysm | 0005112 | |
0000006 | ||
0000007 | ||
Multifactorial inheritance | 0001426 |
Treatment
The resources below provide information about treatment options for this condition. If you have questions about which treatment is right for you, talk to your healthcare professional.
Management Guidelines
- The Society of Interventional Radiology provides information about the management of abdominal aortic aneurysm. Click on the link above to access this information.
Organizations
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Organizations Supporting this Disease
-
The John Ritter Foundation for Aortic Health
11901 Santa Monica Blvd. #410
Los Angeles, CA 90025
Telephone: 310-736-1550
E-mail: https://johnritterfoundation.org/contact/
Website: https://johnritterfoundation.org/ -
The Marfan Foundation
22 Manhasset Avenue
Port Washington, NY 11050
Toll-free: 1-800-8-MARFAN (800-862-7326)
Telephone: +1-516-883-8712
Fax: +1-516-883-8040
E-mail: https://www.marfan.org/secure/ask
Website: https://www.marfan.org/
Organizations Providing General Support
-
American Heart Association
7272 Greenville Avenue
Dallas, TX 75231-4596
Toll-free: 800-242-8721
Telephone: 214-570-5978
E-mail: https://www.heart.org/en/forms/general-questions-and-latest-research-information
Website: https://www.heart.org
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Where to Start
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- The Merck Manuals Online Medical Library provides information on this condition for patients and caregivers.
In-Depth Information
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
The Online Mendelian Inheritance in Man (OMIM)
Online Mendelian Inheritance in Man (OMIM)
The Online Mendelian Inheritance in Man (OMIM) - Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Abdominal aortic aneurysm. Click on the link to view a sample search on this topic.
- UpToDate has an article on Abdominal aortic aneurysm. Click on UpToDate to view the page.
Selected Full-Text Journal Articles
- The American Family Physician provides an online journal article about abdominal aortic aneurysm. Click on the link above to access this article.
References
- John W. Hallett. Abdominal Aortic Aneurysms. Merck Manuals. January, 2008; https://www.merckmanuals.com/home/heart_and_blood_vessel_disorders/aneurysms_and_aortic_dissection/aneurysms.html?qt=abdominal%20aortic%20aneurysm&alt=sh#v722650. Accessed 2/25/2014.
- Weinrauch LA. Abdominal aortic aneurysm. MedlinePlus. August 28, 2008; https://www.nlm.nih.gov/medlineplus/ency/article/000162.htm. Accessed 1/16/2009.
- Ada Hamosh. AORTIC ANEURYSM, FAMILIAL ABDOMINAL, 1; AAA1. OMIM. December 20, 2011; https://omim.org/entry/100070. Accessed 2/25/2014.
- Emile R Mohler III. Epidemiology, risk factors, pathogenesis and natural history of abdominal aortic aneurysm. UpToDate. Waltham, MA: UpToDate; February, 2014; Accessed 2/25/2014.
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