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Disease Profile
Goblet cell carcinoid
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
Unknown
Age of onset
Adult
ICD-10
C18.1
Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
Goblet cell carcinoma; Mucinous carcinoid; GCC;
Categories
Digestive Diseases; Endocrine Diseases; Rare Cancers
Summary
Goblet
Symptoms
Other signs and symptoms may include bowel obstruction, intussusception, gastrointestinal bleeding, and chronic intermittent lower abdominal pain. Rare presentations have reportedly included mesenteric adenitis, and iron deficiency
Treatment
Because of the typical course of the condition and the malignant nature of the
We are unable to give advice to individuals regarding the best course of treatment. We recommend speaking with your health care provider to discuss treatment options.
Organizations
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Organizations Supporting this Disease
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Appendix Cancer/Pseudomyxoma Peritonei Research Foundation (ACPMP Research Foundation)
2021 L Street NW
Suite 101-244
Washington, DC 20036-4909
Telephone: 833-227-6773
E-mail: [email protected]
Website: https://acpmp.org/ -
Carcinoid Cancer Foundation
118 N. Bedford Road, Suite 100
Mt. Kisco, NY 10549-2555
Toll-free: 1-888-722-3132
Telephone: +1-914-683-1001
Fax: +1-914-683-5919
Website: https://www.carcinoid.org/ -
Carcinoid NeuroEndocrine Tumour Society Canada (CNETS Canada)
1608 Blakely Drive
Cornwall, Ontario, K6J 5P4 Canada
Toll-free: 1-844-628-6788
Telephone: +1-416-628-3189
E-mail: [email protected], [email protected]
Website: https://cnetscanada.org/ -
Neuroendocrine Tumor Research Foundation (NETRF)
321 Columbus Avenue, Suite 5R
Boston, MA 02116
Telephone: +1-617-946-1780
E-mail: [email protected]
Website: https://netrf.org/
Organizations Providing General Support
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American Cancer Society
250 Williams Street NW
Atlanta, GA 30329
Toll-free: 1-800-227-2345
Website: https://www.cancer.org
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Where to Start
- The American Cancer Society has an information page on gastrointestinal carcinoid tumor. Click on American Cancer Society to view the information page.
- The Carcinoid Cancer Foundation, Inc. has an information page on carcinoid tumors and related neuroendocrine tumors. Click on Carcinoid Cancer Foundation, Inc. to view the information page.
- The National Cancer Institute provides the most current information on cancer for patients, health professionals, and the general public.
In-Depth Information
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
References
- Paromita Roy and Runjan Chetty. Goblet cell carcinoid tumors of the appendix: An overview. World J Gastrointest Oncol. June 15, 2010; 2(6):251–258. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998842/. Accessed 5/1/2015.
- Information for people affected by Goblet Cell Carcinomas. NET Patient Foundation. July 2014; https://www.netpatientfoundation.org/wp-content/uploads/020-NPF-GOBLET-CELL-CARCINOMA-v6.pdf. Accessed 5/1/2015.
- Plöckinger U, Couvelard A, Falconi M, Sundin A, Salazar R, Christ E, de Herder WW, Gross D, Knapp WH, Knigge UP, Kulke MH, Pape UF; Frascati. Consensus Conference participants. Consensus guidelines for the management of patients with digestive neuroendocrine tumours: well-differentiated tumour/carcinoma of the appendix and goblet cell carcinoma. Neuroendocrinology. Epub 2007 Oct 11 -7;
- Byrn JC, Wang JL, Divino CM, Nguyen SQ, Warner RR. Management of goblet cell carcinoid. J Surg Oncol. 2006 Oct 1;
- Roy P, Chetty R. Goblet cell carcinoid tumors of the appendix: An overview. World Journal of Gastrointestinal Oncology. 2010; 2:251-258. https://www.ncbi.nlm.nih.gov/pubmed/21160637. Accessed 3/21/2012.
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